Tularemia (Rabbit Fever) in Cats

What is tularemia?

Also known as rabbit fever or deer fly fever, tularemia is a rare infection caused by Francisella tularensis bacteria found in the Northern Hemisphere. It is of particular importance because it is a zoonotic disease, which means it can be it can spread to people. It also has the potential to be used as a biological weapon.

The bacteria can survive for long periods in the environment, particularly in warm, moist conditions. It is an intracellular bacteria, predominantly living within the macrophages (a type of white blood cell).

How is tularemia transmitted?

Tularemia can infect more than 100 species of mammal and is widespread through the rabbit, hare, and rodent population. Infection can also occur in birds, amphibians, fish, and reptiles. Cats (and humans) can pick up the disease in the following ways:

  • Oral transmission: Eating infected animals, usually rabbits or rodents or drinking contaminated water
  • Aerosol: Inhaling the bacteria in contaminated soil or via infected animals
  • Vector-borne: Tick, biting-fly, flea or mosquito bite, intermediate hosts feed on an infected animal, during which time they ingest the bacteria, the next time the insect feeds, the bacteria enter the new host

The bacteria can survive for weeks or months in the environment. In the United States, the most common tick vectors include the Lone Star Tick, American Dog Tick and the Rocky Mountain Wood Tick. Tularemia is most prevalent in the warmer months, between April and September. Kittens are usually sicker than healthy adults.

The disease occurs in the Northern Hemisphere which includes the United States, Europe, and Asia.

There are three strains of this bacteria. A, B and C.

  • Type A (F tularensis tularensis) – The most virulent strain, can be found in North America and has recently been found in arthropods in Northern Europe. This strain typically infects wild and domesticated mammals.
  • Type B (F tularensis holarctica) – Produces milder symptoms. Can be found in the Northern Hemisphere, including Continental Europe, North America and parts of Asia. It occurs in water animals.
  • Type C (F novicida) – Has low virulence and is much less common than A and B.

What does tularemia do to infected cats?

  • Ulceroglandular tularemia – This is the most prevalent form of the disease and is acquired by direct contact with an infected animal or vector-borne.
  • Glandular tularemia – Similar to ulceroglandular tularemia, however, there is no ulcer present.
  • Oculoglandular tularemia – This is a form of ulceroglandular tularemia, only the conjunctiva is affected.
  • Oropharyngeal tularemia – Eating or drinking contaminated food or water or inhaling the organism can cause this form of tularemia.
  • Typhoidal tularemia – The systemic form of tularemia without an obvious route of exposure. Micro-abrasions on the skin or via inhalation could explain how the exposure occurred.
  • Pneumonic tularemia (respiratory) – This form is rare, but the most severe and is acquired via inhaling the organism or when the pathogen spreads from other infected sites within the cat’s body.

What are the symptoms of tularemia in cats?

The incubation period of tularemia is between 1-10 days. The severity of the disease varies according to the route of exposure and the strain. Some infected cats will remain subclinical. The most common first symptom to appear is a sudden onset high fever; other symptoms may include:

Also, symptoms can vary depending on the type of tularemia the cat has.

Ulceroglandular tularemia 

An inflamed papule develops at the site of exposure, over time this ulcerates, lymph nodes close to the site become swollen and painful.

Glandular tularemia

Swollen lymph nodes close to the site of inoculation.

Oculoglandular tularemia

Purulent conjunctivitis, most often in one eye, ocular pain, redness, sensitivity to light, enlarged lymph nodes.

Oropharyngeal tularemia

Ulcers on the tonsils, stomatitis (inflamed and sore mouth), swelling of localised lymph nodes, vomiting, and diarrhea.

Typhoidal tularemia

Symptoms of typhoidal tularemia can be a combination of generalised symptoms such as fever, anorexia, and lethargy.

Pneumonic (respiratory) tularemia 

Coughing, difficulty breathing.

As the disease progresses, septicemia, jaundice, enlarged liver and spleen. Possible complications include kidney failure, meningitis, sepsis, hepatitis, disseminated intravascular coagulation and acute respiratory distress.

How is tularemia diagnosed?

Your veterinarian will perform a physical examination of your cat and obtain a medical history from you.

Diagnostic workup:

  • Biochemical profile and complete blood count may reveal elevated liver enzymes if there is liver involvement.
  • Culture and sensitivity to identify bacteria from tissue samples such as lymph nodes, liver or spleen, blood, exudates ulcers and determine which will be the most effective antibiotic.
  • Serology to look for the presence of antibodies in the blood serum. The result may be negative if your cat is tested too early as it can take some time for antibodies to develop.
  • The polymerase chain reaction (PCR) test can detect minute amounts of DNA or RNA which can identify the bacteria when the above tests are inconclusive.

Depending on local regulations, it may be mandatory to report tularemia to the appropriate authorities.

How is tularemia treated?

Antibiotics for 14 days as well as supportive care which may include fluids to correct dehydration and nutritional support. Draining abscesses will be surgically removed.

Due to the infectious nature of tularemia and the zoonotic risk, the cat will be isolated during treatment and hospital staff must wear personal protective gear.

How do cats transmit tularemia to people?

Transmission can occur via exposure to respiratory secretions, bites, and scratches, infected cats can also indirectly pass on the disease via a tick, flea or mosquito bite.


At the moment there is no vaccine for tularemia; therefore prevention is better than cure.

  • Avoid letting your cat outdoors, especially in high-risk areas.
  • If he does go outside, always use either a tick collar or a tick prevention product.
  • Always check your cat for ticks if he has been outside, start at the head and work your way down to the tail.
  • Make sure his flea treatment is up to date.
  • Avoid letting your cat hunt.
  • Avoid handling dead or dying animals. If you do need to dispose of one, wear insect repellent to avoid tick or flea bites and move the animal with a long shovel. Wash clothes immediately afterwards.
  • Don’t keep containers of water lying around your property to reduce mosquito numbers.
  • Always wash your hands after touching any animal.

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